Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice
Shuo He, Lei Huang, Zhuozheng Chen, Ze Yuan, Yue Zhao, Lingfang Zeng, Yi Zhu, Jinlong He
This study shows that the novel nested gene Aff3ir-ORF2 reduces atherosclerosis in mice by inhibiting IRF5-mediated inflammation under disturbed flow conditions.
bioRxiv · Oct 3, 2024Cell Biology