Epithelial FOXP3 Drives Pancreatic Fibrosis through O-glycosylated IL-6
Ruining Gong, Minghan Ren, Junjin Wang, Wenqing Zhang, Shuai Ping, Ke Lei, Qian Yu, Leina Ma, Chao Gao, Chenyang Zhao, Shunli Fu, Jing Xue, Jigang Wang, Hao Sun, Jinsuo Chen, , He Ren
This study identifies epithelial FOXP3 as a driver of pancreatic fibrosis through O-glycosylation of IL-6, revealing a novel mechanism in fibrocarcinogenesis.
bioRxiv · Nov 19, 2025 · PreprintCancer Biology