Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans
Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jıng Zhang, Youbao Zhao
This study shows that Rtf1's HMD domain promotes H2B monoubiquitination and regulates morphogenesis and virulence in Cryptococcus neoformans, independent of Paf1C.
eLife · May 12, 2025Peer-reviewedMolecular Biology