Killer-cell dominance dichotomy governs tumor immune networks and stratifies inflamed cancers
Anlin Li, Zhixin Yu, Wei Zhang, H J Chang, Sirui Feng, Xuan Yang, Kangqiao Xiong, Lina He, Zerui Zhao, Lujun Shen, Zihui Tan, Wei Du, L Y Zhong, Xu Zhang, Yun Hu, , Shaodong Hong
The paper identifies a dichotomy in killer-cell dominance in tumors, distinguishing between exhausted CD8+ T cells and CD56dimCD16hi NK cells, and shows its impact on immunotherapy response.
bioRxiv · Jun 19, 2026 · PreprintImmunology