Li Zhang

Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins

The paper reanalyzes original data and conducts new experiments to show that neurexins have distinct functions in different synapse types.

Adipose GPD2 Couples Glycolytic Signals to Epigenetic Control of Metabolic Homeostasis

This study identifies GPD2 as a key regulator linking glycolytic signals to epigenetic control of thermogenesis and metabolic homeostasis in adipose tissue.

Single-nuclear RNA sequencing reveals an ATF3-independent sensory-neuron program after surgical incision

This study uses single-nuclear RNA sequencing to show that ATF3 is not required for postoperative pain, and identifies c-Jun as a potential ATF3-independent driver of the injury program.

CPS: Mapping Physical Coordinates to High-Fidelity Spatial Transcriptomics via Privileged Multi-Scale Context Distillation

CPS maps physical coordinates to high-fidelity spatial transcriptomics using a multi-scale context distillation strategy, achieving state-of-the-art imputation and denoising performance.

Killer-cell dominance dichotomy governs tumor immune networks and stratifies inflamed cancers

The paper identifies a dichotomy in killer-cell dominance in tumors, distinguishing between exhausted CD8+ T cells and CD56dimCD16hi NK cells, and shows its impact on immunotherapy response.

Elimination of intramuscular immunoglobulin accumulation alleviates Duchenne Muscular Dystrophy

This study identifies IgG accumulation in dystrophin-deficient muscle as a driver of DMD progression and shows that B cell depletion reduces it, offering a potential therapeutic strategy.