Strong genotype-by-genotype and genotype-by-environment interactions induced by antibiotic resistance mutations
Alicia H. Williams, Ian Gooi, Madelaine Boggan, Ziqing Liu, Andrew D. Letten, Jan Engelstädter
This study examines how genetic background and temperature affect the fitness effects of antibiotic resistance mutations across three bacterial species, finding strong genotype-by-genotype and genotype-by-environment interactions.
bioRxiv · Dec 4, 2025 · PreprintEvolutionary Biology