Automated continuous evolution of proteins in vivo
Ziwei Zhong, Brandon G. Wong, Arjun Ravikumar, Garri A. Arzumanyan, Ahmad S. Khalil, Chang C. Liu
This paper introduces ACE, a platform for automated continuous evolution of proteins in vivo, showing it can achieve desired functions like drug resistance and improved enzyme activity through real-time feedback control.
ACS Synthetic Biology · May 6, 2020Peer-reviewedSynthetic Biology