Genomic Analysis of Progenitors in Viral Infection Implicates Glucocorticoids as Suppressors of Plasmacytoid Dendritic Cell Generation
Yeara Jo, Trever T. Greene, Carolina Chiale, Kai Zhang, Ziyan Fang, Simone Dallari, Nuha Marooki, Wei Wang, Elina I. Zúñiga
This study investigates how viral infection affects DC progenitor development, finding that glucocorticoids suppress pDC generation by altering transcriptional and epigenetic programs.
Proceedings of the National Academy of Sciences · Apr 28, 2025Peer-reviewedImmunology