Author

Yeara Jo

University of California, BerkeleyORCID 0000-0002-1340-1968Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 4 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

David H. RauletiD· 4 shared Chenyu ZhangiD· 2 shared Elizabeth AndrewsiD· 2 shared Abigail MendeiD· 1 shared Alejandro N Medina· 1 shared Alexander EthelliD· 1 shared Alexandros KarampatzakisiD· 1 shared Alice PengiD· 1 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersImmunology

David H. RauletORCID

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Author profile →

5 papers

Recent·Most cited

ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity

Yeara Jo, Alexandros Karampatzakis, Seung Won Lee, Alice Peng, Zaina Ghouri, Monsserratt Moya, Elizabeth Andrews, Harrison Sudholz, Chenyu Zhang, Berna Bou Tayeh, Alejandro N Medina, Jiucheng Ding, Robert A. Saxton, Ziyang Zhang, Yang Shi, , David H. Raulet

This study identifies ITPKB as a regulator of NK cell desensitization, showing its inhibition enhances antitumor immunity in murine and human models.

bioRxiv · Jul 17, 2026 · PreprintImmunology

Viral capsid delivery of cGAMP enhances STING-dependent antitumor immune response

Paul Huang, Yeara Jo, Hannah S. Martin, Rutger David Luteijn, David H. Raulet, Matthew B. Francis

This study shows that delivering cGAMP via bacteriophage MS2 nanoparticles enhances STING activation and antitumor immunity in mice.

bioRxiv · Jul 1, 2026 · PreprintImmunology

Intra-Tumoral Treg Ablation Unleashes NK Cell-Mediated Control of CD8 T Cell-Resistant Tumors

Chenyu Zhang, Charles Chien, Eglė Jurgaitytė, Koharu Sakiyama, Alissa Bockman, Yeara Jo, Seungwon Lee, Stephanie L. Silveria, Elizabeth Andrews, Abigail Mende, Lily Zhang, K. Christopher García, Allon Wagner, Michel J.P. DuPage, David H. Raulet

Intra-tumoral Treg ablation enhances NK cell-mediated tumor control by restoring IL-2 production, effective against both MHC I+ and MHC I- cancers without systemic toxicity.

Science Immunology · Apr 10, 2026Peer-reviewedImmunology

Genomic Analysis of Progenitors in Viral Infection Implicates Glucocorticoids as Suppressors of Plasmacytoid Dendritic Cell Generation

Yeara Jo, Trever T. Greene, Carolina Chiale, Kai Zhang, Ziyan Fang, Simone Dallari, Nuha Marooki, Wei Wang, Elina I. Zúñiga

This study investigates how viral infection affects DC progenitor development, finding that glucocorticoids suppress pDC generation by altering transcriptional and epigenetic programs.

Proceedings of the National Academy of Sciences · Apr 28, 2025Peer-reviewedImmunology

Binary outcomes of enhancer activity underlie stable random monoallelic expression

Djem U. Kissiov, Alexander Ethell, Sean Chen, Natalie K. Wolf, Chen‐Yu Zhang, Susanna M. Dang, Yeara Jo, Katrine N. Madsen, Ishan Paranjpe, Angus Y. Lee, Bryan Chim, Stefan Adi Muljo, David H. Raulet

The paper investigates enhancer activity's role in random monoallelic expression (RME) of NK cell receptor genes, finding that enhancer properties drive RME and suggest it is a general phenomenon.

eLife · Mar 22, 2022Peer-reviewedMolecular Biology