TRIM32-UBQLN2-p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates
Ziyan He, Jiechao Zhou, Rongzhen Zhang, Fei Meng, David W. Nauen, Juan Carlos Troncoso, Paul F. Worley, Wenchi Zhang
This study identifies a molecular pathway involving TRIM32, UBQLN2, and p62 that forms condensates promoting TDP-43 aggregation in neurodegenerative diseases.
bioRxiv · Feb 14, 2026 · PreprintNeuroscience