Hierarchical Lineage Tracing Reveals Diverse Pathways of AML Treatment Resistance
Rachel Saxe, Hugh Stuart, Abigail C. Marshall, Fahiima Abdullahi, Zoë Chen, Francesco E. Emiliani, Aaron McKenna
This study uses FLARE to track AML cell lineage evolution under AraC treatment, revealing resistance mechanisms and validating them in a clinical cohort.
bioRxiv · Feb 27, 2025 · PreprintCancer Biology