Mitochondrial oxidation of the carbohydrate fuel driven by pyruvate dehydrogenase robustly enhances stemness of older and geriatric Intestinal Stem Cells
Syed Ahmed, Aasem Awwad, Nerise Eddy, Garrett Weber, Zrar Shahid, Zubin Sethi, Jonathan Labampa, Robert Murphy, Eric W. Roth, Kyle Gustafson, Hardik Shah, Sinju Sundaresan
This study shows that enhancing pyruvate dehydrogenase activity in aged intestinal stem cells improves their stemness by increasing mitochondrial ATP production.
Communications Biology · Sep 10, 2026Peer-reviewedCell Biology