Eric W. Roth

Mitochondrial oxidation of the carbohydrate fuel driven by pyruvate dehydrogenase robustly enhances stemness of older and geriatric Intestinal Stem Cells

This study shows that enhancing pyruvate dehydrogenase activity in aged intestinal stem cells improves their stemness by increasing mitochondrial ATP production.

Statistical Analysis of Three-Dimensional Chromatin Packing Domains Determined by Chromatin Scanning Transmission Electron Microscopy (ChromSTEM)

The paper introduces ChromSTEM, a method for high-resolution 3D imaging of chromatin structure, and finds that chromatin forms well-defined domains around 100 nm in radius with radially decreasing mass-density.

Improving cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles

The paper improves cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles in bacterial extracts to enhance membrane-bound functionality.

Apparent size and morphology of bacterial microcompartments varies with technique

The paper shows that different imaging techniques produce varying apparent sizes and morphologies of bacterial microcompartments from Salmonella enterica serovar Typhimurium LT2, and provides guidelines for sample preparation.

Quantifying Three-dimensional Chromatin Organization Utilizing Scanning Transmission Electron Microscopy: ChromSTEM

The paper introduces ChromSTEM, a method to quantify 3D chromatin organization using electron microscopy, and finds chromatin is densely packed with heterochromatin having higher density than euchromatin.