Author

Joseph Matheson

University of ArizonaORCID 0000-0001-5083-8248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:ecology & biodiversity· 1 Research Focus:genome assembly· 1 Organism:human· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Joanna MaseliD· 2 shared Ulises HernándeziD· 2 shared Walid MawassiD· 2 shared Jeremy J. BergiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersEvolutionary Biology

Joanna MaselORCID

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2 papers

Recent·Most cited

Rare variants drive high variance in human ancestral fitness at mutation-selection-drift balance

Ulises Hernández, Walid Mawass, Joseph Matheson, Joanna Masel

The paper estimates human genetic load variation due to rare and ultra-rare deleterious mutations, showing significant ancestral fitness differences between individuals.

bioRxiv · Jul 31, 2026 · PreprintEvolutionary Biology

Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation

Walid Mawass, Ulises Hernández, Joseph Matheson, Jeremy J. Berg, Joanna Masel

The paper compares the effects of mutational drought and meltdown on extinction risk in small populations, finding mutational drought is more significant in stable and changing environments.

Proceedings of the Royal Society B Biological Sciences · Jun 3, 2026Peer-reviewedEvolutionary Biology