Li F. Chan

The paper shows that reducing Crh in the PVH of mice decreases anxiety-like behaviors, but manipulating Crh levels through adrenal insufficiency or dexamethasone does not affect anxiety behaviors.

The paper identifies 88 novel rare disease-gene associations using a burden analysis framework on whole genome sequencing data from the 100,000 Genomes Project, with potential clinical impact for undiagnosed cases.