Denise H. Harold

The paper investigates how vitamin B12 and folic acid affect mitochondrial DNA heteroplasmy in mice and suggests potential sex-specific effects in humans.

The paper introduces Mito-SiPE, a PCR-free mitochondrial DNA enrichment method that reduces amplification and alignment artifacts, enabling ultra-deep sequencing of mtDNA in mouse tissues.

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.

This study performs a large GWAS of Alzheimer's disease, identifies four new risk loci, and highlights pathways involving immunity, lipid metabolism, and APP/Aβ processing.