Author

Henk J. Blom

Erasmus MCORCID 0000-0001-5202-9241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

George J. G. RuijteriD· 2 shared Marcel J. T. ReindersiD· 2 shared Michiel BongaertsiD· 2 shared Ramon Bonte· 2 shared Serwet DemirdasiD· 2 shared Ans van der Ploeg· 1 shared Edwin H. Jacobs· 1 shared Esmée OussoreniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

George J. G. RuijterORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicineMolecular Genetics and MetabolismPeer-reviewedMay 25, 2022

Prioritizing disease-causing metabolic genes by integrating metabolomics with whole exome sequencing data

Michiel Bongaerts, Ramon Bonte, Serwet Demirdas…·George J. G. Ruijter

This paper introduces Reafect, a computational method that integrates metabolomics and whole exome sequencing to prioritize disease-causing genes in inborn errors of metabolism, showing improved accuracy in identifying causative variants.

12 citations

humanwhole-exome sequencing

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BioinformaticsMetabolitesPeer-reviewedDec 25, 2020

Screening for inborn errors of metabolism using untargeted metabolomics and out-of-batch controls

Michiel Bongaerts, Ramon Bonte, Serwet Demirdas…·George J. G. Ruijter

The paper develops a normalization method for untargeted metabolomics data to reduce batch effects and improve detection of metabolic biomarkers using out-of-batch controls.

17 citations

humanmetabolomics

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