Author

Serwet Demirdas

Erasmus MCORCID 0000-0001-5496-4153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Research Focus:batch correction / integration· 1 Research Focus:differential expression· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

George J. G. RuijteriD· 2 shared Henk J. BlomiD· 2 shared Marcel J. T. ReindersiD· 2 shared Michiel BongaertsiD· 2 shared Ramon Bonte· 2 shared Alexandre ReymondiD· 1 shared Alfredo BruscoiD· 1 shared Amanda G. NoyesiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

George J. G. RuijterORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintSep 29, 2022

Deleterious, protein-altering variants in the X-linked transcriptional coregulator ZMYM3 in 22 individuals with a neurodevelopmental delay phenotype

Susan M. Hiatt, Slavica Trajkova, Matteo Rossi Sebastiano…·Gregory M. Cooper

The paper identifies ZMYM3 variants in 22 individuals with neurodevelopmental delay, showing recurrent mutations, phenotypic overlap, and functional effects, supporting ZMYM3 as a novel NDD gene.

DOI 10.1101/2022.09.29.22279724

humanstatistical model

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Genetic & Genomic MedicineMolecular Genetics and MetabolismPeer-reviewedMay 25, 2022

Prioritizing disease-causing metabolic genes by integrating metabolomics with whole exome sequencing data

Michiel Bongaerts, Ramon Bonte, Serwet Demirdas…·George J. G. Ruijter

This paper introduces Reafect, a computational method that integrates metabolomics and whole exome sequencing to prioritize disease-causing genes in inborn errors of metabolism, showing improved accuracy in identifying causative variants.

12 citations

humanwhole-exome sequencing

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BioinformaticsMetabolitesPeer-reviewedDec 25, 2020

Screening for inborn errors of metabolism using untargeted metabolomics and out-of-batch controls

Michiel Bongaerts, Ramon Bonte, Serwet Demirdas…·George J. G. Ruijter

The paper develops a normalization method for untargeted metabolomics data to reduce batch effects and improve detection of metabolic biomarkers using out-of-batch controls.

17 citations

humanmetabolomics

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