BioinformaticsbioRxivPreprint
Memo-Patho: Bridging Local-Global Transmembrane Protein Contexts with Contrastive Pretraining for Alignment-Free Pathogenicity Prediction
Yihang Bao, Zhe Liu, Fangyi Zhao…·Guan Ning Lin
Memo-Patho predicts pathogenicity of transmembrane protein mutations using an alignment-free deep learning framework with contrastive pretraining, achieving high accuracy on benchmark datasets and manual curation.
DOI 10.1101/2025.05.18.654712