Guan Ning Lin

BaiZe predicts and interprets cellular responses to perturbations using a multi-view framework, showing effectiveness across diverse contexts and improved predictions with ATAC-seq data.

This paper introduces RLAgent, an LLM-based framework for RNA-ligand interaction modeling that enables interactive, code-free prediction at the RNA region level.

Memo-Patho predicts pathogenicity of transmembrane protein mutations using an alignment-free deep learning framework with contrastive pretraining, achieving high accuracy on benchmark datasets and manual curation.

This study benchmarks encoding strategies for non-coding SNPs across QTL prediction tasks, emphasizing interactions between encoding, models, and preprocessing.

This study identifies genetic determinants of bone microarchitecture using GWAS and shows its causal links to health outcomes like rheumatoid arthritis and fracture risk.

This paper introduces Methven, a deep learning framework that predicts non-coding mutation effects on DNA methylation at single-cell resolution, showing superior performance in prioritizing functional mutations.

The paper introduces Haplotype Function Score (HFS) to improve genetic association analysis and polygenic prediction by replacing genotypes with functional scores, showing increased causal findings and better cross-ancestry prediction.

EMO predicts non-coding mutation-induced up- and down-regulation of gene expression using deep learning, achieving high performance across variant distances and cell types.

The paper analyzes full-length splicing isoforms in the developing human brain to identify isoform-level changes associated with neurodevelopmental disorders and highlights the importance of studying mutations at the isoform level.

MutPred2 identifies pathogenic amino acid variants, predicts their molecular mechanisms, and validates their functional impact in neurodevelopmental disorders.

This study uses a k-means based unsupervised feature selection method to identify biomarkers associated with different clinical phases of Huntington's disease.