Effects of dopamine D2 and opioid receptor antagonism on the trade-off between model-based and model-free behavior in healthy volunteers
Nace Mikuš, Sebastian Korb, Claudia Massaccesi, Christian Gausterer, Irene Graf, Matthäus Willeit, Christoph Eisenegger, Claus Lamm, Giorgia Silani, Christoph D. Mathys
This study investigates how dopamine D2 and opioid receptor antagonism affects the balance between model-based and model-free behavior in healthy volunteers, finding that D2 antagonism increases model-based behavior while opioid antagonism has no significant effect.
eLife · Nov 23, 2022Peer-reviewedNeuroscience