Ronald Keiflin

Reward Memories Bias Instrumental Rule Selection via the Orbitofrontal-to-Secondary Motor cortex Pathway

This study shows that reward memories bias abstract rule selection in decision-making via the orbitofrontal-to-secondary motor cortex pathway.

Orbitofrontal circuits for context-gated reward predictions

This study investigates how orbitofrontal cortex circuits regulate reward predictions in different contexts using optogenetics and computational modeling in rats.

Partially dissociable roles of the Orbitofrontal cortex and dorsal Hippocampus in context-dependent (hierarchical) reward predictions and contextual inference in learning

This study investigates the roles of the orbitofrontal cortex and dorsal hippocampus in context-dependent hierarchical reward predictions and learning using chemogenetic inactivations in rats.

Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

This study examines sex differences in contextual control over reward prediction in rats, finding females show slower acquisition but more robust performance with increased orbitofrontal cortex activation.

From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement

This study identifies distinct roles of VTA and SNc dopamine neurons in instrumental learning through behavioral tasks and optogenetic manipulations, showing they support different reinforcement mechanisms.

Phasic Activation of Ventral Tegmental, but not Substantia Nigra, Dopamine Neurons Promotes Model-Based Pavlovian Reward Learning

This study shows that VTA dopamine neuron activation supports model-based reward learning, while SNc dopamine neuron activation only reinforces instrumental responses.