Max Van Houcke

The paper applies T-cell receptor sequencing and epitope annotation tools to quality control and immune monitoring of TIL products by identifying tumor-specific clones and screening for off-cancer reactivity.

IMMREP25 evaluates TCR:pMHC binding prediction for unseen peptides, showing improved performance with structural modeling but still below random guessing.

clusTCR is a Python tool for fast clustering of large CDR3 sequences, offering improved speed over existing methods while maintaining comparable accuracy.