Nanoscale 3D profiling of the T cell membrane reveals CD2 enrichment at microvilli tips, positioning adhesion near TCR zones in the immunological synapse
Suzi Kim, Elianna Zhi-Xiang Lai, Hamidreza Akhbariyoon, Aleksandra Klimas, Emma F. DiBernardo, Yongxin Zhao, En Cai
This study uses NanoMAP to reveal CD2 enrichment at microvilli tips in T cells, showing its spatial relationship with TCRs and LFA-1 during immunological synapse formation.
bioRxiv · Aug 20, 2026 · PreprintImmunology