Systems BiologyPLoS Computational BiologyPeer-reviewed
A modular approach for modeling the cell cycle based on functional response curves
Jolan De Boeck, Jan Rombouts, Lendert Gelens
The paper introduces a modular approach to model the cell cycle using functional response curves, demonstrating how ultrasensitive responses, S-shaped responses, and time delays can be combined to capture bistable behavior and cell cycle dynamics.