Author

Cameron T. Roots

The University of Texas at AustinORCID 0000-0001-6219-3168Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 2

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Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

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Jeffrey E. BarrickiD· 2 shared Alexis M. HilliD· 1 shared Claus O. WilkeiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersSynthetic Biology

Jeffrey E. BarrickORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintNov 28, 2024

Modeling and measuring how codon usage modulates the relationship between burden and yield during protein overexpression in bacteria

Cameron T. Roots, Alexis M. Hill, Claus O. Wilke, Jeffrey E. Barrick

The paper develops a stochastic gene expression model to quantify how codon usage bias affects burden and yield during protein overexpression in bacteria, finding an overoptimization domain that reduces yield.

1 citation

E. coliproteomics

𝕏 PostBluesky

Synthetic BiologySynthetic BiologyPeer-reviewedJan 1, 2024

CryptKeeper: a negative design tool for reducing unintentional gene expression in bacteria

Cameron T. Roots, Jeffrey E. Barrick

CryptKeeper predicts and mitigates unintended gene expression in bacterial DNA sequences by analyzing translational burden and identifying off-target elements.

5 citations

bacteria (other)DNA methylation

𝕏 PostBluesky