Essential Dynamics of CB1 Receptor-Agonist Complexes: Implications for Signalling Bias
Daniel M. J. Fellner, Michelle Glass, Daniel P. Furkert
This study uses molecular dynamics to show that different CB1 receptor agonists induce distinct conformations leading to biased signalling through differential coupling to G proteins and beta-arrestins.
bioRxiv · Mar 25, 2024 · PreprintNeuroscience