Ganesh A. Viswanathan

The paper uses Boolean modeling to identify a feedback loop in TNFR1 signaling that influences apoptosis and suggests targeting Comp1-IKK* interaction as a therapeutic strategy.

This study identifies the synergistic role of pJNK and pAKT in modulating Caspase3 activation to control TNFα-induced apoptosis and proposes a predictive model for therapeutic strategies.

The paper characterizes operating regimes of a phosphorylation-dephosphorylation cycle under retroactivity and identifies regime transitions caused by changes in retroactivity strength.

The paper identifies four operating regimes in an enzymatic cascade using ensemble-level data and shows that RIQR and RM ratios can determine the regime from experimental observables.