GenomicsbioRxivPreprint
Mutational signature decomposition with deep neural networks reveals origins of clock-like processes and hypoxia dependencies
Clàudia Serrano Colomé, Oleguer Canal, Vladimir B. Seplyarskiy, Donate Weghorn
The paper introduces SigNet, a deep learning method for mutational signature decomposition, showing improved accuracy and robustness in estimating signature contributions in cancer genomes.
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