Palette polygenic risk score framework improves risk prediction by capturing clinical heterogeneity of type 2 diabetes
Akimitsu Miyake, Hayato Tanabe, Akira Narita, Takafumi Ojima, Tomoki Kyosaka, Chinatsu Gocho, Rieko Sakurai, Jun Takayama, Hajime Yamakage, Kenichi Tanaka, Junichiro James Kazama, Noriko Satoh‐Asahara, Michio Shimabukuro, Gen Tamiya
The paper introduces a polygenic risk score framework that improves type 2 diabetes risk prediction by accounting for clinical subtypes and pathway-specific contributions.
medRxiv · Jan 13, 2026 · PreprintGenetic & Genomic Medicine