Akira Narita

Genome-wide Association Study of Social Isolation in 63 497 Japanese Individuals from the General Population

This study identifies genetic loci associated with social isolation in a Japanese population using GWAS, finding associations with ACADSB, HMX3, LINC02315, and LRFN5.

Palette polygenic risk score framework improves risk prediction by capturing clinical heterogeneity of type 2 diabetes

The paper introduces a polygenic risk score framework that improves type 2 diabetes risk prediction by accounting for clinical subtypes and pathway-specific contributions.

Genomic analyses reveal new insights into Alzheimer's disease

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

Deep embedded clustering by relevant scales and genome-wide association study in autism

The paper clusters ASD patients using a deep embedded algorithm and performs cluster-based GWAS, identifying 90 significant loci associated with ASD subgroups.

A fine-scale genetic map of the Japanese population

This paper constructs a fine-scale genetic map of the Japanese population using whole-genome sequencing data, identifies recombination hotspots, and shows improved haplotype phasing and imputation accuracy.

Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

This study identifies 118 candidate causal genes and 21 novel lipid loci on the X chromosome through a multi-ancestry meta-analysis of blood lipid levels, revealing sex-biased effects and pleiotropy with cardiovascular and hormonal traits.

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

This paper integrates GWAS data with functional genomic datasets to identify regulatory mechanisms and causal genes underlying lipid-related traits.

A global atlas of genetic associations of 220 deep phenotypes

Cross-population GWAS of 220 phenotypes in BioBank Japan, UK Biobank, and FinnGen (n=628,000) identifies 5,343 previously unreported loci and decomposes summary statistics into latent genetic components for disease subtyping.

Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs

The paper introduces Japonica Array NEO, a SNP array for the Japanese population with enhanced coverage and disease risk SNPs, showing high imputation quality and utility in genotyping cohorts.

Clustering by phenotype and genome-wide association study in autism

The paper uses clustering and genome-wide association studies to identify subgroups in autism spectrum disorder and finds significant loci associated with these subgroups.