Use of Antibody Structural Information in Disease Prediction Models Reveals Antigen Specific B Cell Receptor Sequences in Bulk Repertoire Data
Onyekachi Nwogu, Kirandeep K. Gill, Carolina Moore, John W. Kroner, Wan-Chi Chang, Jeff W. Burkle, Mariana L. Stevens, Asel Baatyrbek kyzy, Emily R. Miraldi, Jocelyn M. Biagini Myers, Ashley Lynn Devonshire, Leah Claire Kottyan, Justin T. Schwartz, Amal Assa’ad, Lisa Joy Martin, , Krishna M. Roskin
This study uses structural information of antibodies to identify convergent antibodies in bulk IgH data, improving disease prediction for food sensitization and matching HIV prediction performance.
bioRxiv · Dec 10, 2024 · PreprintImmunology