BioinformaticsbioRxivPreprint
De novo design of protein-binding aptamers through deep reinforcement learning assembly of nucleic acid fragments
Gaoxing Guo, Liangwei Guo, Jiaqiang Qian…·Qiang Huang
This paper introduces AiDTA, a deep reinforcement learning method for de novo design of protein-binding aptamers, achieving high-affinity DNA aptamers for disease-related proteins.
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