ImmunologyJournal of Crohn s and ColitisPeer-reviewed
Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis
Elisa Melón-Ardanaz, Marisol Veny, Ana Maria Corraliza…·Azucena Salas
The paper investigates resistance to JAK inhibitors in UC by analyzing single-cell RNA data from responders and non-responders, identifying hyperactivation of myeloid cells as a key mechanism.