Elisa Melón-Ardanaz

The paper identifies TL1A-driven cellular and transcriptomic changes in rectal mucosa of Crohn's disease patients with perianal fistulizing disease, revealing a novel TL1A-LT1{beta}2/IL-22 axis independent of TNF signaling.

The paper investigates resistance to JAK inhibitors in UC by analyzing single-cell RNA data from responders and non-responders, identifying hyperactivation of myeloid cells as a key mechanism.

The paper integrates single-cell RNA-seq datasets across the GI tract to identify epithelial metaplasia in inflammatory diseases, showing its role in inflammation through immune cell interactions.

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.