Leslie Sieburth

Neighboring codon adjacent nucleotides have a conserved influence on mRNA decay

The paper investigates how codon usage and context affect mRNA decay rates in Arabidopsis, finding that codon optimality explains 21% of decay rate variance and that codon context also influences stability.

Decay drives RNA abundance regulation using three distinct regulatory mechanisms

The paper identifies three regulatory mechanisms by which RNA decay influences RNA abundance changes in Arabidopsis, including synergistic, oppositional, and decay-alone effects.