Single-Shot Design of a Cyclic Peptide Inhibitor of HIV-1 Membrane Fusion with EvoBind
Diandra Daumiller, Federica Giammarino, Qiuzhen Li, Anders B. Sönnerborg, Rafael Ceña Diez, Patrick Bryant
This paper introduces EvoBind, an AI method to design cyclic peptides that inhibit HIV-1 membrane fusion, demonstrating potent inhibition of two HIV-1 strains with no toxicity.
bioRxiv · Apr 30, 2025 · PreprintPharmacology & Toxicology