BioinformaticsbioRxivPreprint
Screen-VarCal: An Interpretable Probabilistic Framework for Recalibrating ACMG Rule-Based Variant Classification in Preventive Medicine
Divya Mishra, Alok Tiwari, Shivani Srivastava…·Anmol Kapoor
Screen-VarCal recalibrates ACMG variant classifications from InterVar to reduce false positives in preventive genomics using logistic regression and isotonic adjustment.
DOI 10.1101/2025.09.23.678112