Ye Yue

This paper introduces Com-2seq, a method that integrates 16S and shotgun metagenomic data to improve statistical efficiency in testing differential abundance.

The paper extends PERMANOVA to test microbiome mediation effects by incorporating exposure and outcome as covariates, showing improved power and error control over existing methods.

The paper introduces LDM-med, a new mediation analysis method for microbiome data that controls type I error and FDR, outperforming existing methods in power and flexibility.