MYH11 rare variant augments aortic growth and induces cardiac hypertrophy and heart failure with pressure overload
Zhen Zhou, Kgosi Hughes, Nisha Saif, Hyoseon Kim, Michael P. Massett, Mingjie Zheng, Alana C. Cecchi, Dongchuan Guo, David R. Murdock, Ping Pan, Jelita S. Clinton, Jun Wang, John M. Greally, Dianna M. Milewicz
This study investigates the effect of a rare MYH11 variant in mice, finding it does not cause aortic disease but leads to cardiac hypertrophy and heart failure under pressure overload.
PLoS Genetics · Jul 14, 2025Peer-reviewedGenetics