BioinformaticsbioRxivPreprint
ARUNA: Slice-based self-supervised imputation for upscaling DNA methylation sequencing assays
Janmajay Singh, Wei-Hao Lee, Grace Yu, Vicky Yao
Aruna upscales sparse DNA methylation data from RRBS to whole-genome resolution using a self-supervised denoising autoencoder, outperforming existing methods in simulations and real data.
DOI 10.64898/2026.01.29.702677