GeneticseLifePeer-reviewed
Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations
Chiara Auwerx, Marie C. Sadler, Tristan Woh…·Eleonora Porcu
The paper develops a multi-omics Mendelian randomization framework to identify transcript-metabolite-trait causal triplets and shows it outperforms classical transcriptome-wide MR by integrating multiple omics layers.
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