Author

Jingru Tian

Yale UniversityORCID 0000-0001-6944-4556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Dingyao ZhangiD· 5 shared Jun LüiD· 4 shared Archibald EnninfuliD· 1 shared Christine RodeniD· 1 shared Daqian GaoiD· 1 shared Donglu Bai· 1 shared Haikuo LiiD· 1 shared Hao Xing· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersBioinformatics

Dingyao ZhangORCID

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Author profile →

5 papers

Recent·Most cited

Determining cellular phylogeny and migration at high resolution in spatial genomics

Dingyao Zhang, Yunzhe Jiang, Xuezhu Yu, Donglu Bai, Jingru Tian, Archibald Enninful, Xiaolong Tian, Haikuo Li, Yiran Huo, Yuhang Chen, Nan Yao, Jiaqi Li, Zhiyuan Chu, Zhiliang Bai, Rong Fan, , Mark Gerstein

StarTrak infers cellular migration and phylogeny by integrating somatic variants, spatial data, and transcriptomics at single-pixel resolution in spatial genomics.

bioRxiv · Oct 18, 2026 · PreprintBioinformatics

Alteration of skin fibroblast steady state contributes to healing outcomes

Yaqing Huang, N.-K. Wang, Hao Xing, Jingru Tian, Dingyao Zhang, Daqian Gao, Henry C. Hsia, Jun Lü, Micha Sam Brickman Raredon, Themis R. Kyriakides

This study identifies pro-regenerative features in TSP2-deficient fibroblasts through single-cell analysis and functional assays, showing enhanced migration, proliferation, and neurogenesis.

bioRxiv · Dec 6, 2024 · PreprintPathology

In Silico Design of siRNAs Targeting Existing and Future Respiratory Viruses with VirusSi

Dingyao Zhang, Jingru Tian, Yadong Wang, Jun Lü

This paper introduces VirusSi, a computational pipeline for designing siRNAs against existing and future respiratory viruses, showing pre-design feasibility for SARS-CoV-2 and other viruses.

Bioinformatics · Mar 15, 2022Peer-reviewedBioinformatics

Post-transcriptional Regulation is the Major Driver of microRNA Expression Variation

Dingyao Zhang, Jingru Tian, Christine Roden, Jun Lü

The paper shows that post-transcriptional regulation, not transcription, mainly drives variation in mature miRNA expression across tissues and cancers.

bioRxiv · Jan 7, 2020 · PreprintBioinformatics

microRNA seedless sites attenuate strong-seed-site-mediated target repression

Xujun Wang, Jingru Tian, Peng Cui, Stephen Mastriano, Dingyao Zhang, Hongyu Zhao, Hui Juan Lu, Ye Ding, Jun Lü

The paper shows that seedless miRNA binding sites reduce the effectiveness of seed site-mediated target repression in 3' UTRs, affecting miRNA-mediated gene regulation.

bioRxiv · Nov 11, 2019 · PreprintBioinformatics