Christine Roden

Sequence and structure of protein binding sites in RNA impact biomolecular condensates

The paper investigates how RNA-protein binding site context, not just valence, affects biomolecular condensate properties in Ashbya gossypii.

Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication

The paper investigates how RNA-RNA interactions in viral replication are controlled by biomolecular condensates, showing that sequence complementarity and condensate properties influence RNA organization.

Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures

This study shows that SARS-CoV-2 N-protein uses two distinct RNA motifs, both requiring dsRNA, to drive phase separation at specific temperatures, enabling multiple viral functions.

Post-transcriptional Regulation is the Major Driver of microRNA Expression Variation

The paper shows that post-transcriptional regulation, not transcription, mainly drives variation in mature miRNA expression across tissues and cancers.

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms

The paper co-sequences microRNAs and mRNAs in single cells to show miRNA variability contributes to non-genetic cell-to-cell heterogeneity and identifies new regulatory relationships.