Fuzhong Zhang

Designing a hybrid in silico/in-cell controller robust to process-model mismatch associated with dynamically regulated enzyme overexpression

This paper demonstrates a hybrid in silico/in-cell controller that reduces toxicity from excessive enzyme overexpression by adapting to process-model mismatch in engineered E. coli.

Trade-offs in biosensor optimization for dynamic pathway engineering

This paper uses multiobjective optimization to analyze trade-offs in biosensor design for dynamic pathway engineering, showing improved production in E. coli.

Metabolite sequestration enables rapid recovery from fatty acid depletion in Escherichia coli

This study shows that Escherichia coli uses metabolite sequestration to rapidly recover from fatty acid depletion by releasing a transcriptional regulator.