Christopher J. Woodruff

This paper demonstrates strain-level resolution and quantification of bacterial microbiomes using nanopore sequencing of the ribosomal RNA operon, showing accurate relative abundance quantification over multiple orders of magnitude.

The paper investigates using nanopore sequencing and denoising to achieve strain-level resolution and abundance estimation in a mock microbiome.

The paper presents a method for strain-level microbial sample characterization using long reads and MAPQ scores, achieving better strain differentiation than existing tools.