Hongzhu Qu

DNA methylation reveals molecular heterogeneity and urate excretion-associated subtypes of gout

The paper identifies DNA methylation subtypes of gout associated with urate excretion using methylation profiling and machine learning, achieving high predictive performance.

Spatial and Single-Cell Transcriptomics Decipher the Crosstalk Environment of DEFB1+ Cancer Cells and IFI30+ Macrophages in Intrahepatic Cholangiocarcinoma

The paper integrates single-cell and spatial transcriptomics to analyze the tumor microenvironment of intrahepatic cholangiocarcinoma, identifying a key cholangiocyte-macrophage interaction that contributes to immunotherapy resistance.

EryDB: a transcriptomic profile database for erythropoiesis and erythroid-related diseases

EryDB is a database that collects and integrates transcriptomic data for erythropoiesis and erythroid-related diseases, enabling analysis and visualization of gene expression across species and tissues.

The dynamic interactive network of long non-coding RNAs and chromatin accessibility facilitates erythroid differentiation

The paper investigates the interaction between long non-coding RNAs and chromatin accessibility during erythroid differentiation, identifying stage-specific regulatory networks and key lncRNAs involved in the process.

Common postzygotic mutational signature in multiple healthy adult tissues related to embryonic hypoxia

The paper identifies a common postzygotic mutational signature across healthy tissues linked to embryonic hypoxia, observed in both normal and some tumor samples.