BioinformaticsbioRxivPreprint
Spatial and Single-Cell Transcriptomics Decipher the Crosstalk Environment of DEFB1+ Cancer Cells and IFI30+ Macrophages in Intrahepatic Cholangiocarcinoma
Guoliang Wang, Hang Meng, Meng Li…·Hongzhu Qu
The paper integrates single-cell and spatial transcriptomics to analyze the tumor microenvironment of intrahepatic cholangiocarcinoma, identifying a key cholangiocyte-macrophage interaction that contributes to immunotherapy resistance.