The paper uses sensitivity analysis and support vector ranking to prioritize higher-order interactions in time series Wnt pathway data, revealing how these interactions change over time.

4 citations

statistical model

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 6, 2018

Sensitivity analysis based ranking reveals unknown biological hypotheses for down regulated genes in time buffer during administration of PORCN-WNT inhibitor ETC-1922159 in CRC

Shriprakash Sinha

The paper develops a search engine to prioritize unknown biological hypotheses among down-regulated genes after administering the PORCN-WNT inhibitor ETC-1922159, revealing higher-order gene interactions in the Wnt signaling pathway.

DOI 10.1101/180927

humanbulk RNA-seq

𝕏 PostBluesky

Systems BiologybioRxivPreprintAug 8, 2017

Prioritizing 2nd and 3rd order interactions via support vector ranking using sensitivity indices on static Wnt measurements

Shriprakash Sinha

DOI 10.1101/059469

statistical model

𝕏 PostBluesky

Systems BiologybioRxivPreprintMay 10, 2017

Sensitivity analysis of Wnt β-catenin based transcription complex might bolster power-logarithmic psychophysical law and reveal preserved gene gene interactions

Shriprakash Sinha

The paper uses sensitivity analysis on computational models of the Wnt β-catenin transcription complex to explore psychophysical laws and gene-gene interactions in normal and tumor samples.

2 citations

statistical model

𝕏 PostBluesky