Author

Justin J. King

Simon Fraser UniversityORCID 0000-0001-7040-595XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1

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David Nicolas Giuseppe HuebertiD· 1 shared Mani LarijaniiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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1 shared paperBiochemistry

David Nicolas Giuseppe HuebertORCID

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1 paper

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BiochemistrybioRxivPreprintSep 29, 2025

AID/APOBEC3 Dynamic Catalytic Pockets and AID-α7 Regulation Mechanisms

David Nicolas Giuseppe Huebert, Justin J. King, Mani Larijani

The paper uses molecular dynamics to analyze catalytic pocket dynamics of AID/APOBEC3 enzymes, finding that A3G-CD2 is predominantly open while most AID/APOBECs are closed or indeterminate, with specific residues influencing pocket states and catalytic activity.

DOI 10.1101/2025.09.29.679391

biophysical modelingprotein folding & dynamics

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